Selected Publications from the Griffin Lab (for a complete list, see Google Scholar)
Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin
Griffin GK*, Booth CAG, Togami K, Chung SS, Ssozi D, Verga JA, Bouyssou JM, Lee YS, Shanmugam V, Hornick JL, LeBoeuf NR, Morgan EA, Bernstein BE, Hovestadt V*, van Galen P*, Lane AA*.
Nature. 2023 Jun 7 (online ahead of print). PMID: 37286599.
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
Griffin GK*, Wu J*, Iracheta-Vellve A* , Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT*, Bernstein BE*.
Nature. 2021 Jul;595(7866):309-314. PMID: 33953401.
Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma
Griffin GK*, Weirather JL*, Roemer MGM*, Lipschitz M, Kelley A, Chen PH, Gusenleitner D, Jeter E, Pak C, Gjini E, Chapuy B, Rosenthal MH, Xu J, Chen BJ, Sohani AR, Lovitch SB, Abramson JS, Ishizuka JJ, Kim AI, Jacobson CA, LaCasce AS, Fletcher CD, Neuberg D, Freeman GJ, Hodi FS, Wright K, Ligon AH, Jacobsen ED, Armand P, Shipp MA, Rodig SJ.
Blood. 2021 Mar 11;137(10):1353-1364. PMID: 32871584.
Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade
Chapuy B*, Stewart C*, Dunford AJ*, Kim J, Wienand K, Kamburov A, Griffin GK, Chen PH, Lako A, Redd RA, Cote CM, Ducar MD, Thorner AR, Rodig SJ, Getz G*, Shipp MA*.
Blood. 2019 Dec 26;134(26):2369-2382. PMID: 31697821.
The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4-positive T cells that are PD-1-negative
Patel SS, Weirather JL, Lipschitz M, Lako A, Chen PH, Griffin GK, Armand P, Shipp MA, Rodig SJ.
Blood. 2019 Dec 5;134(23):2059-2069. PMID: 31697809.
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
Miller BC*, Sen DR*, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN.
Nature Immunology. 2019 Mar;20(3):326-336. PMID: 30778252.
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
van Galen P*, Hovestadt V*, Wadsworth MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE.
Cell. 2019 Mar 7;176(6):1265-1281. PMID: 30827681.
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Ishizuka JJ*, Manguso RT*, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.
Nature. 2019 Jan;565(7737):43-48. PMID: 30559380.
Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma
Shanmugam V, Griffin GK, Jacobsen ED, Fletcher CDM, Sholl LM, Hornick JL.
Modern Pathology. 2019 Jun;32(6):830-843. PMID: 30626916.
Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-kB regulatory genes
Griffin GK, Sholl LM, Lindeman NI, Fletcher CD, Hornick JL.
Modern Pathology. 2016 Jan;29(1):67-74. PMID: 26564005.
NF-kB directs dynamic super enhancer formation in inflammation and atherogenesis
Brown JD*, Lin CY*, Duan Q*, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE*, Plutzky J*.
Molecular Cell. 2014 Oct 23;56(2):219-231. PMID: 25263595.
IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation
Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ*, Lichtman AH*.
Journal of Immunology. 2012 Jun 15;188(12):6287-99. PMID: 22566565.
Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment
Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N.
Journal of Immunology. 2011 Oct 1;187(7):3521-9. PMID: 21873519.
Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin
Griffin GK*, Booth CAG, Togami K, Chung SS, Ssozi D, Verga JA, Bouyssou JM, Lee YS, Shanmugam V, Hornick JL, LeBoeuf NR, Morgan EA, Bernstein BE, Hovestadt V*, van Galen P*, Lane AA*.
Nature. 2023 Jun 7 (online ahead of print). PMID: 37286599.
Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
Griffin GK*, Wu J*, Iracheta-Vellve A* , Patti JC, Hsu J, Davis T, Dele-Oni D, Du PP, Halawi AG, Ishizuka JJ, Kim SY, Klaeger S, Knudsen NH, Miller BC, Nguyen TH, Olander KE, Papanastasiou M, Rachimi S, Robitschek EJ, Schneider EM, Yeary MD, Zimmer MD, Jaffe JD, Carr SA, Doench JG, Haining WN, Yates KB, Manguso RT*, Bernstein BE*.
Nature. 2021 Jul;595(7866):309-314. PMID: 33953401.
Spatial signatures identify immune escape via PD-1 as a defining feature of T-cell/histiocyte-rich large B-cell lymphoma
Griffin GK*, Weirather JL*, Roemer MGM*, Lipschitz M, Kelley A, Chen PH, Gusenleitner D, Jeter E, Pak C, Gjini E, Chapuy B, Rosenthal MH, Xu J, Chen BJ, Sohani AR, Lovitch SB, Abramson JS, Ishizuka JJ, Kim AI, Jacobson CA, LaCasce AS, Fletcher CD, Neuberg D, Freeman GJ, Hodi FS, Wright K, Ligon AH, Jacobsen ED, Armand P, Shipp MA, Rodig SJ.
Blood. 2021 Mar 11;137(10):1353-1364. PMID: 32871584.
Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade
Chapuy B*, Stewart C*, Dunford AJ*, Kim J, Wienand K, Kamburov A, Griffin GK, Chen PH, Lako A, Redd RA, Cote CM, Ducar MD, Thorner AR, Rodig SJ, Getz G*, Shipp MA*.
Blood. 2019 Dec 26;134(26):2369-2382. PMID: 31697821.
The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4-positive T cells that are PD-1-negative
Patel SS, Weirather JL, Lipschitz M, Lako A, Chen PH, Griffin GK, Armand P, Shipp MA, Rodig SJ.
Blood. 2019 Dec 5;134(23):2059-2069. PMID: 31697809.
Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
Miller BC*, Sen DR*, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, Griffin GK, Maleri S, Comstock DE, Weiss SA, Brown FD, Panda A, Zimmer MD, Manguso RT, Hodi FS, Rodig SJ, Sharpe AH, Haining WN.
Nature Immunology. 2019 Mar;20(3):326-336. PMID: 30778252.
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
van Galen P*, Hovestadt V*, Wadsworth MH, Hughes TK, Griffin GK, Battaglia S, Verga JA, Stephansky J, Pastika TJ, Lombardi Story J, Pinkus GS, Pozdnyakova O, Galinsky I, Stone RM, Graubert TA, Shalek AK, Aster JC, Lane AA, Bernstein BE.
Cell. 2019 Mar 7;176(6):1265-1281. PMID: 30827681.
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Ishizuka JJ*, Manguso RT*, Cheruiyot CK, Bi K, Panda A, Iracheta-Vellve A, Miller BC, Du PP, Yates KB, Dubrot J, Buchumenski I, Comstock DE, Brown FD, Ayer A, Kohnle IC, Pope HW, Zimmer MD, Sen DR, Lane-Reticker SK, Robitschek EJ, Griffin GK, Collins NB, Long AH, Doench JG, Kozono D, Levanon EY, Haining WN.
Nature. 2019 Jan;565(7737):43-48. PMID: 30559380.
Identification of diverse activating mutations of the RAS-MAPK pathway in histiocytic sarcoma
Shanmugam V, Griffin GK, Jacobsen ED, Fletcher CDM, Sholl LM, Hornick JL.
Modern Pathology. 2019 Jun;32(6):830-843. PMID: 30626916.
Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-kB regulatory genes
Griffin GK, Sholl LM, Lindeman NI, Fletcher CD, Hornick JL.
Modern Pathology. 2016 Jan;29(1):67-74. PMID: 26564005.
NF-kB directs dynamic super enhancer formation in inflammation and atherogenesis
Brown JD*, Lin CY*, Duan Q*, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE*, Plutzky J*.
Molecular Cell. 2014 Oct 23;56(2):219-231. PMID: 25263595.
IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation
Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ*, Lichtman AH*.
Journal of Immunology. 2012 Jun 15;188(12):6287-99. PMID: 22566565.
Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment
Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N.
Journal of Immunology. 2011 Oct 1;187(7):3521-9. PMID: 21873519.