Research in the Griffin Lab
Our lab seeks to identify new and better cancer immunotherapies for patients.
We use a collaborative and interdisciplinary research model that draws from multiple fields, including cancer epigenomics, tumor immunology, genome editing, and computational biology, among others.
We seek a systematic understanding of:
1. How cancer cells adapt to and avoid detection by the immune system ("immune escape")
2. Cancer proteins that can be targeted therapeutically to restore, amplify, or engage anti-tumor immunity
We are particularly interested in defining how the cancer epigenome adapts to selective pressures applied by the immune system. Prior work from our group and others has identified epigenetic silencing of repetitive elements, including endogenous retroviruses, as a touchpoint for multiple immunoregulatory pathways in cancer. We seek to exploit these pathways therapeutically to enhance the efficacy and scope of immunotherapy for patients.
To learn more about our science please see our recent publications or contact us directly.
Our lab seeks to identify new and better cancer immunotherapies for patients.
We use a collaborative and interdisciplinary research model that draws from multiple fields, including cancer epigenomics, tumor immunology, genome editing, and computational biology, among others.
We seek a systematic understanding of:
1. How cancer cells adapt to and avoid detection by the immune system ("immune escape")
2. Cancer proteins that can be targeted therapeutically to restore, amplify, or engage anti-tumor immunity
We are particularly interested in defining how the cancer epigenome adapts to selective pressures applied by the immune system. Prior work from our group and others has identified epigenetic silencing of repetitive elements, including endogenous retroviruses, as a touchpoint for multiple immunoregulatory pathways in cancer. We seek to exploit these pathways therapeutically to enhance the efficacy and scope of immunotherapy for patients.
To learn more about our science please see our recent publications or contact us directly.